New Synthesis and Tritium Labeling of a Selective Ligand for Studying High-Affinity γ-Hydroxybutyrate (GHB) Binding Sites-Reference-Cited by-同舟云学术

New Synthesis and Tritium Labeling of a Selective Ligand for Studying High-Affinity γ-Hydroxybutyrate (GHB) Binding Sites

Published:2013-10-04 Issue:20 Volume:56 Page:8201-8205
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Vogensen Stine B.¹,Marek Aleš²³,Bay Tina¹,Wellendorph Petrine¹,Kehler Jan⁴,Bundgaard Christoffer⁴,Frølund Bente¹,Pedersen Martin H. F.²,Clausen Rasmus P.¹

Affiliation:

1. Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark

2. The Hevesy Laboratory, DTU Nutech, Technical University of Denmark, 4000 Roskilde, Denmark

3. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 16610 6 Prague, Czech Republic

4. DiscoveryChemistry and DMPK, H. Lundbeck A/S, Ottiliavej 9, DK-2500 Valby, Denmark

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm4011719

Reference23 articles.

1. Gamma-hydroxybutyric acid: an endogenous neuromodulator with abuse potential?

2. Gamma-hydroxybutyrate – a drug of abuse

3. Behavioral analyses of GHB: Receptor mechanisms

4. Specific gamma-hydroxybutyrate-binding sites but loss of pharmacological effects of gamma-hydroxybutyrate in GABAB(1)-deficient mice

5. The distribution of γ-hydroxybutyrate-induced Fos expression in rat brain: Comparison with baclofen

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