Configurational Reassignment and Improved Preparation of the Competitive IL-6 Receptor Antagonist 20R,21R-Epoxyresibufogenin-3-formate-Reference-Cited by-同舟云学术

Configurational Reassignment and Improved Preparation of the Competitive IL-6 Receptor Antagonist 20R,21R-Epoxyresibufogenin-3-formate

Published:2012-02-23 Issue:4 Volume:75 Page:661-668
ISSN:0163-3864
Container-title:Journal of Natural Products
language:en
Short-container-title:J. Nat. Prod.

Author:

Boos Terrence L.¹,Cheng Kejun¹,Greiner Elisabeth¹,Deschamps Jeffrey R.²,Jacobson Arthur E.¹,Rice Kenner C.¹

Affiliation:

1. Drug Design and Synthesis Section, Chemical Biology Research Branch, NIDA and NIAAA, National Institutes of Health, Department of Health and Human Services, 5625 Fishers Lane, Room 4N03, Bethesda, Maryland 20892-9415, United States

2. Center for Biomolecular Science and Engineering, Naval Research Laboratory (NRL), Washington, D.C. 20375, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Analytical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/np2008957

Reference22 articles.

1. Isolation and Structure of a 20,21-Epoxybufenolide Series from “Ch'an Su”

2. Inhibitory Effects of Bufadienolides on Interleukin-6 in MH-60 Cells

3. Suppression of cancer cachexia by 20S,21-epoxy-resibufogenin-3-acetate—a novel nonpeptide IL-6 receptor antagonist

4. Biological Activity of a Novel Nonpeptide Antagonist to the Interleukin-6 Receptor 20S,21-Epoxy-resibufogenin-3-formate

5. 3-O-Formyl-20R,21-epoxyresibufogenin suppresses IL-6–type cytokine actions by targeting the glycoprotein 130 subunit: Potential clinical implications

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