Design and Synthesis of Pyrrolidine-5,5-trans-lactams (5-Oxohexahydropyrrolo[3,2-b]pyrroles) as Novel Mechanism-Based Inhibitors of Human Cytomegalovirus Protease. 2. Potency and Chirality-Reference-Cited by-同舟云学术

Design and Synthesis of Pyrrolidine-5,5-trans-lactams (5-Oxohexahydropyrrolo[3,2-b]pyrroles) as Novel Mechanism-Based Inhibitors of Human Cytomegalovirus Protease. 2. Potency and Chirality

Published:2001-12-05 Issue:1 Volume:45 Page:1-18
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Borthwick Alan D.¹,Crame Andrew J.¹,Ertl Peter F.¹,Exall Anne M.¹,Haley Terry M.¹,Hart Graham J.¹,Mason Andrew M.¹,Pennell Andrew M. K.¹,Singh Onkar M. P.¹,Weingarten Gordon G.¹,Woolven James M.¹

Affiliation:

1. Department of Medicinal Chemistry CVU UK, GlaxoSmithKline Research and Development, Medicines Research Centre, Gunnels Wood Road, Stevenage, Herts SG1 2NY, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0102203

Reference18 articles.

1. Herpesvirus proteases: targets for novel antiviral drugs

2. The Herpesvirus Proteases as Targets for Antiviral Chemotherapy

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