Synthesis and Biological Evaluation of Pyrrolinic Isosteres of Rilmenidine. Discovery of cis-/trans-Dicyclopropylmethyl-(4,5-dimethyl-4,5-dihydro-3H- pyrrol-2-yl)-amine (LNP 509), an I1 Imidazoline Receptor Selective Ligand with Hypotensive Activity-Reference-Cited by-同舟云学术

Synthesis and Biological Evaluation of Pyrrolinic Isosteres of Rilmenidine. Discovery of cis-/trans-Dicyclopropylmethyl-(4,5-dimethyl-4,5-dihydro-3H- pyrrol-2-yl)-amine (LNP 509), an I1 Imidazoline Receptor Selective Ligand with Hypotensive Activity

Published:2001-03-24 Issue:10 Volume:44 Page:1588-1593
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Schann Stephan¹,Bruban Véronique¹,Pompermayer Kenia¹,Feldman Josiane¹,Pfeiffer Bruno¹,Renard Pierre¹,Scalbert Elizabeth¹,Bousquet Pascal¹,Ehrhardt Jean-Daniel¹

Affiliation:

1. Laboratoire de Neurobiologie et Pharmacologie Cardiovasculaire, Université Louis Pasteur, Faculté de Médecine, 11, rue Humann, 67000 Strasbourg, France, ADIR, 1, rue Carle Hebert, 92415 Courbevoie Cedex, France, and IRIS, 6, place des Pléiades, 92415 Courbevoie Cedex, France

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm001111b

Reference47 articles.

1. The I1-imidazoline receptor

2. Reduction in Viscosity of Cystic Fibrosis Sputum in Vitro by Gelsolin

3. Isolation and partial purification of a clonidine-displacing endogenous brain substance

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