Glycan-Imprinted Nanoparticle as Artificial Neutralizing Antibody for Efficient HIV-1 Recognition and Inhibition

Author:

Zhou Juntao1,Wang Libian1,Liu Xiaoyan23,Gai Yanxin1,Dong Mingming2ORCID,Wang Chu1,Ali Muhammad Mujahid1,Ye Mingliang2ORCID,Yu Xianghui1,Hu Lianghai1ORCID

Affiliation:

1. Center for Supramolecular Chemical Biology, National Engineering Laboratory of AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, Jilin 130012, China

2. CAS Key Laboratory of Separation Sciences for Analytical Chemistry, National Chromatographic R&A Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences Dalian, Liaoning 116023, China

3. University of Chinese Academy of Sciences, Beijing, 100049, China

Funder

State Key Laboratory of Analytical Chemistry for Life Sciences

National Key Research and Development Program of China

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Reference49 articles.

1. UNAIDS. Fact Sheet: Global HIV statistics; Joint United Nations Programme on HIV/AIDS: Geneva, Switzerland, 2023. www.unaids.org/sites/default/files/media_asset/UNAIDS_FactSheet_en.pdf (2023-11-06).

2. Exploitation of glycosylation in enveloped virus pathobiology

3. Glycans in HIV-1 vaccine design – engaging the shield

4. Env Exceptionalism: Why Are HIV-1 Env Glycoproteins Atypical Immunogens?

5. Broadly Neutralizing Antiviral Antibodies

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