Unveiling Mechanical Activation: GAIN Domain Unfolding and Dissociation in Adhesion GPCRs

Author:

Fu Chaoyu12,Huang Wenmao12,Tang Qingnan1,Niu Minghui3,Guo Shiwen2,Langenhan Tobias4,Song Gaojie3,Yan Jie1256ORCID

Affiliation:

1. Department of Physics, National University of Singapore, Singapore 117551, Singapore

2. Mechanobiology Institute, National University of Singapore, Singapore 117411, Singapore

3. School of Life Sciences, East China Normal University, Shanghai 200241, China

4. Rudolf Schönheimer Institute of Biochemistry, Division of General Biochemistry, Medical Faculty, Leipzig University, Leipzig 04103, Germany

5. Centre for Bioimaging Sciences, National University of Singapore, Singapore 117557, Singapore

6. Joint School of National University of Singapore and Tianjin University, International Campus of Tianjin University, Binhai New City, Fuzhou 350207, China

Funder

Ministry of Education - Singapore

Deutsche Forschungsgemeinschaft

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Mechanical Engineering,Condensed Matter Physics,General Materials Science,General Chemistry,Bioengineering

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