Surface-Patterned DNA Origami Rulers Reveal Nanoscale Distance Dependency of the Epidermal Growth Factor Receptor Activation

Author:

Mayer Ivy1,Karimian Tina2,Gordiyenko Klavdiya1,Angelin Alessandro1,Kumar Ravi3,Hirtz Michael3ORCID,Mikut Ralf4,Reischl Markus4,Stegmaier Johannes45,Zhou Lu6,Ma Rui6,Nienhaus Gerd Ulrich678ORCID,Rabe Kersten S.1ORCID,Lanzerstorfer Peter2ORCID,Domínguez Carmen M.1ORCID,Niemeyer Christof M.1ORCID

Affiliation:

1. Institute for Biological Interfaces (IBG-1), Karlsruhe Institute of Technology (KIT), 76344 Eggenstein-Leopoldshafen, Germany

2. School of Engineering, University of Applied Sciences Upper Austria, 4600 Wels, Austria

3. Institute of Nanotechnology (INT) & Karlsruhe Nano Micro Facility (KNMF), Karlsruhe Institute of Technology (KIT), 76344 Eggenstein-Leopoldshafen, Germany

4. Institute for Automation and Applied Informatics (IAI), Karlsruhe Institute of Technology (KIT), 76344 Eggenstein-Leopoldshafen, Germany

5. Institute of Imaging and Computer Vision, RWTH Aachen University, 52074 Aachen, Germany

6. Institute of Applied Physics (APH), Karlsruhe Institute of Technology (KIT), 76049 Karlsruhe, Germany

7. Institute of Biological and Chemical Systems (IBCS) and Institute of Nanotechnology (INT), Karlsruhe Institute of Technology (KIT), 76021 Karlsruhe, Germany

8. Department of Physics, University of Illinois at Urbana−Champaign, Urbana, Illinois 61801, United States

Funder

Helmholtz-Gemeinschaft

?sterreichische Forschungsf?rderungsgesellschaft

Deutsche Forschungsgemeinschaft

Publisher

American Chemical Society (ACS)

Subject

Mechanical Engineering,Condensed Matter Physics,General Materials Science,General Chemistry,Bioengineering

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