Predictive Models for GABAA/Benzodiazepine Receptor Subtypes: Studies of Quantitative Structure−Activity Relationships for Imidazobenzodiazepines at Five Recombinant GABAA/Benzodiazepine Receptor Subtypes [αxβ3γ2 (x = 1−3, 5, and 6)] via Comparative Molecular Field Analysis-Reference-Cited by-同舟云学术

Predictive Models for GABAA/Benzodiazepine Receptor Subtypes: Studies of Quantitative Structure−Activity Relationships for Imidazobenzodiazepines at Five Recombinant GABAA/Benzodiazepine Receptor Subtypes [αxβ3γ2 (x = 1−3, 5, and 6)] via Comparative Molecular Field Analysis

Published:1998-09-17 Issue:21 Volume:41 Page:4130-4142
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Huang Qi¹,Liu Ruiyan¹,Zhang Puwen¹,He Xiaohui¹,McKernan Ruth¹,Gan Tong¹,Bennett Dennis W.¹,Cook James M.¹

Affiliation:

1. Department of Chemistry, University of Wisconsin-Milwaukee, P.O. Box 413, Milwaukee, Wisconsin 53201, and Department of Biochemistry, Merck Sharp and Dohme Research Laboratories, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm980317y

Reference57 articles.

1. Skolnick, P. Is receptor heterogeneity relevant to the anxiolytic actions of benzodiazepine receptor ligands? InNew Concepts in Anxiety; Briley, M., Files, S., Eds.; MacMillian Press: London, 1991; Vol. 4, pp 109−202.

2. Electrophysiology of GABAA and GABAB receptor subtypes

3. Molecular biology of GABA A receptors

4. 1,4-Benzodiazepines. Chemistry and Some Aspects of the Structure-Activity Relationship

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