Discovery of a Highly Potent and Selective MEK Inhibitor: GSK1120212 (JTP-74057 DMSO Solvate)-Reference-Cited by-同舟云学术

Discovery of a Highly Potent and Selective MEK Inhibitor: GSK1120212 (JTP-74057 DMSO Solvate)

Published:2011-02-28 Issue:4 Volume:2 Page:320-324
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Abe Hiroyuki¹,Kikuchi Shinichi¹,Hayakawa Kazuhide¹,Iida Tetsuya¹,Nagahashi Noboru¹,Maeda Katsuya¹,Sakamoto Johei¹,Matsumoto Noriaki¹,Miura Tomoya¹,Matsumura Koji¹,Seki Noriyoshi¹,Inaba Takashi¹,Kawasaki Hisashi¹,Yamaguchi Takayuki¹,Kakefuda Reina¹,Nanayama Toyomichi¹,Kurachi Hironori¹,Hori Yoshikazu¹,Yoshida Takayuki²,Kakegawa Junya²,Watanabe Yoshihiro²,Gilmartin Aidan G.³,Richter Mark C.³,Moss Katherine G.³,Laquerre Sylvie G.³

Affiliation:

1. Central Pharmaceutical Research Institute, Japan Tobacco, 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan

2. Pharmaceutical Frontier Research Laboratory, Japan Tobacco, 1-13-2 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan

3. Oncology R&D, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ml200004g

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1. Targeting the mitogen-activated protein kinase cascade to treat cancer