Identification of 1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea Hydrochloride (CEP-32496), a Highly Potent and Orally Efficacious Inhibitor of V-RAF Murine Sarcoma Viral Oncogene Homologue B1 (BRAF) V600E-Reference-Cited by-同舟云学术

Identification of 1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea Hydrochloride (CEP-32496), a Highly Potent and Orally Efficacious Inhibitor of V-RAF Murine Sarcoma Viral Oncogene Homologue B1 (BRAF) V600E

Published:2012-01-23 Issue:3 Volume:55 Page:1082-1105
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Rowbottom Martin W.¹,Faraoni Raffaella¹,Chao Qi¹,Campbell Brian T.¹,Lai Andiliy G.¹,Setti Eduardo¹,Ezawa Maiko¹,Sprankle Kelly G.¹,Abraham Sunny¹,Tran Lan¹,Struss Brian¹,Gibney Michael¹,Armstrong Robert C.¹,Gunawardane Ruwanthi N.¹,Nepomuceno Ronald R.¹,Valenta Ianina¹,Hua Helen¹,Gardner Michael F.¹,Cramer Merryl D.¹,Gitnick Dana¹,Insko Darren E.¹,Apuy Julius L.¹,Jones-Bolin Susan²,Ghose Arup K.²,Herbertz Torsten²,Ator Mark A.²,Dorsey Bruce D.²,Ruggeri Bruce²,Williams Michael²,Bhagwat Shripad¹,James Joyce¹,Holladay Mark W.¹

Affiliation:

1. Ambit Biosciences, 4215 Sorrento Valley Boulevard, San Diego, California 92121, United States

2. Cephalon, Inc., 145 Brandywine Parkway, West Chester, Pennsylvania 19380, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm2009925

Reference42 articles.

1. The Raf/MEK/ERK pathway: new concepts of activation

2. Mutations of the BRAF gene in human cancer