Synthesis, Structure−Activity Relationships, and in Vivo Evaluations of Substituted Di-tert-butylphenols as a Novel Class of Potent, Selective, and Orally Active Cyclooxygenase-2 Inhibitors. 2. 1,3,4- and 1,2,4-Thiadiazole Series-Reference-Cited by-同舟云学术

Synthesis, Structure−Activity Relationships, and in Vivo Evaluations of Substituted Di-tert-butylphenols as a Novel Class of Potent, Selective, and Orally Active Cyclooxygenase-2 Inhibitors. 2. 1,3,4- and 1,2,4-Thiadiazole Series

Published:1999-03-19 Issue:7 Volume:42 Page:1161-1169
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Song Yuntao¹,Connor David T.¹,Sercel Anthony D.¹,Sorenson Roderick J.¹,Doubleday Robert¹,Unangst Paul C.¹,Roth Bruce D.¹,Beylin Vlad G.¹,Gilbertsen Richard B.¹,Chan Kam¹,Schrier Denis J.¹,Guglietta Antonio¹,Bornemeier Dirk A.¹,Dyer Richard D.¹

Affiliation:

1. Departments of Chemistry, Chemical Development, Biochemistry, and Immunopathology, Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, 2800 Plymouth Road, Ann Arbor, Michigan 48105

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm980570y

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1. Gastrointestinal Damage Associated with the Use of Nonsteroidal Antiinflammatory Drugs

2. Indomethacin and Aspirin abolish Prostaglandin Release from the Spleen

3. TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue

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