Investigating the Relationship between in Vitro–in Vivo Genotoxicity: Derivation of Mechanistic QSAR Models for in Vivo Liver Genotoxicity and in Vivo Bone Marrow Micronucleus Formation Which Encompass Metabolism-Reference-Cited by-同舟云学术

Investigating the Relationship between in Vitro–in Vivo Genotoxicity: Derivation of Mechanistic QSAR Models for in Vivo Liver Genotoxicity and in Vivo Bone Marrow Micronucleus Formation Which Encompass Metabolism

Published:2012-01-24 Issue:2 Volume:25 Page:277-296
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Mekenyan Ovanes G.¹,Petkov Petko I.¹,Kotov Stefan V.¹,Stoeva Stoyanka¹,Kamenska Verginia B.¹,Dimitrov Sabcho D.¹,Honma Masamitsu²,Hayashi Makoto²³,Benigni Romualdo⁴,Donner E. Maria⁵,Patlewicz Grace⁵

Affiliation:

1. Laboratory of Mathematical Chemistry (LMC), As. Zlatarov University, Bourgas, Bulgaria

2. Division of Genetics and Mutagenesis, National Institute of Health Sciences, Tokyo, Japan

3. Biosafety Research Center, Foods, Drugs and Pesticides, Iwata, Japan

4. Environment and Health Department, Istituto Superiore di Sanita', Rome, Italy

5. DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, Delaware 19714-0050, United States

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/tx200547s

Reference81 articles.

1. Searches for ultimate chemical carcinogens and their reactions with cellular macromolecules

2. Fundamental structural alerts to potential carcinogenicity or noncarcinogenicity

3. Definitive relationships among chemical structure, carcinogenicity and mutagenicity for 301 chemicals tested by the U.S. NTP

4. The use of structure–activity relationship analysis in the food contact notification program

5. Derivation and Validation of Toxicophores for Mutagenicity Prediction

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