High-Throughput Study of Phenytoin Solid Dispersions: Formulation Using an Automated Solvent Casting Method, Dissolution Testing, and Scaling-Up-Reference-Cited by-同舟云学术

High-Throughput Study of Phenytoin Solid Dispersions: Formulation Using an Automated Solvent Casting Method, Dissolution Testing, and Scaling-Up

Published:2008-07-16 Issue:5 Volume:10 Page:637-643
ISSN:1520-4766
Container-title:Journal of Combinatorial Chemistry
language:en
Short-container-title:J. Comb. Chem.

Author:

Barillaro Valéry¹,Pescarmona Paolo P.¹,Van Speybroeck Michiel¹,Thi Thao Do¹,Van Humbeeck Jan¹,Vermant Jan¹,Augustijns Patrick¹,Martens Johan A.¹,Van Den Mooter Guy¹

Affiliation:

1. Laboratory for Pharmacotechnology and Biopharmacy, K.U. Leuven, Gasthuisberg O&N2, Herestraat 49, 3000 Leuven, Belgium, Centre for Surface Chemistry and Catalysis, K.U. Leuven, Kasteelpark Arenberg 23, 3001 Heverlee, Belgium, MTM Department, K.U. Leuven, Kasteelpark Arenberg 44, 3001 Heverlee, Belgium, and CIT Department, K.U. Leuven, Willem de Croylaan 46, 3001 Heverlee, Belgium

Publisher

American Chemical Society (ACS)

Subject

General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/cc8000585

Reference28 articles.

1. Kinetics of Diphenylhydantoin Disposition in Man

2. Complexation of phenytoin with some hydrophilic cyclodextrins: effect on aqueous solubility, dissolution rate, and anticonvulsant activity in mice

3. Improved dissolution and bioavailability of phenytoin by sulfobutylether-β-cyclodextrin ((SBE)7m-β-CD) and hydroxypropyl-β-cyclodextrin (HP-β-CD) complexation

4. Effect of Sugar-Modified .BETA.-Cyclodextrins on Dissolution and Absorption Characteristics of Phenytoin.

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