Synthesis of A83586C Analogs with Potent Anticancer and β-Catenin/ TCF4/Osteopontin Inhibitory Effects and Insights Into How A83586C Modulates E2Fs and pRb-Reference-Cited by-同舟云学术

Synthesis of A83586C Analogs with Potent Anticancer and β-Catenin/ TCF4/Osteopontin Inhibitory Effects and Insights Into How A83586C Modulates E2Fs and pRb

Published:2009-01-06 Issue:3 Volume:11 Page:737-740
ISSN:1523-7060
Container-title:Organic Letters
language:en
Short-container-title:Org. Lett.

Author:

Hale Karl J.¹,Manaviazar Soraya¹,Lazarides Linos¹,George Jonathan¹,Walters Marcus A.¹,Cai Jiaqiang¹,Delisser Vern M.¹,Bhatia Gurpreet S.¹,Peak S. Andrew¹,Dalby Stephen M.¹,Lefranc Amandine¹,Chen Ying-Nan P.¹,Wood Alexander W.¹,Crowe Paul¹,Erwin Pauline¹,El-Tanani Mohamed¹

Affiliation:

1. The School of Chemistry & Chemical Engineering and the Centre for Cancer Research and Cell Biology (CCRCB), Queen’s University Belfast (QUB), Stranmillis Road, Belfast BT9 5AG, U.K., The Department of Oncology, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, and The Christopher Ingold Laboratories, UCL, 20 Gordon Street, London WC1H 0AJ U.K.

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ol802818f

Reference13 articles.

1. Small-molecule antagonists of the oncogenic Tcf/β-catenin protein complex

2. Agelastatin A: a novel inhibitor of osteopontin-mediated adhesion, invasion, and colony formation

3. A83586C, a new depsipeptide antibiotic.

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