Development and Validation of the First Liquid Chromatography-Tandem Mass Spectrometry Assay for Simultaneous Quantification of Multiple Antiretrovirals in Meconium

Author:

Himes Sarah K.1,Scheidweiler Karl B.1,Tassiopoulos Katherine2,Kacanek Deborah3,Hazra Rohan4,Rich Kenneth5,Huestis Marilyn A.1

Affiliation:

1. Chemistry and Drug Metabolism Section, Intramural Research Program, National Institute on Drug Abuse, 251 Bayview Boulevard, Baltimore, Maryland 21224, United States

2. Epidemiology Department, Harvard School of Public Health, Boston, Massachusetts 02115, United States

3. Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, Massachusetts 02115, United States

4. Pediatric Adolescent and Maternal AIDS Branch, NICHD, NIH, Bethesda, Maryland 20892, United States

5. Pediatrics Department, University of Illinois at Chicago, Chicago, Illinois 60612, United States

Publisher

American Chemical Society (ACS)

Subject

Analytical Chemistry

Reference36 articles.

1. World Health Organization. Towards universal access. Progressreport (2010. Available athttp://www.who.int/hiv/pub/2010progressreport/en/index.html.

2. Estimated Number of Infants Born to HIV-Infected Women in the United States and Five Dependent Areas, 2006

3. Panel on Treatment of HIV-Infected Pregnant Women and Prevention of Perinatal Transmission. Recommendations for Use of Antiretroviral Drugs in Pregnant HIV-1-Infected Women for Maternal Health and Interventions to Reduce Perinatal HIV Transmission in the United States (Updated July 2012) . Department of Health and Human Services. Available athttp://aidsinfo.nih.gov/contentfiles/lvguidelines/perinatalgl.pdf.

4. Persistent mitochondrial dysfunction in HIV-1-exposed but uninfected infants

5. Tenofovir treatment at 30 mg/kg/day can inhibit cortical bone mineralization in growing rhesus monkeys (Macaca mulatta)

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