Comparing the Conformational Behavior of a Series of Diastereomeric Cyclic Urea HIV-1 Inhibitors Using the Low Mode:Monte Carlo Conformational Search Method

Author:

Parish Carol A.1,Yarger Matthew1,Sinclair Kent1,Dure Myrianne1,Goldberg Alla1

Affiliation:

1. Department of Chemistry, Hobart and William Smith Colleges, Geneva, New York 14456

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Reference91 articles.

1. Hodge, C. N.; Straatsma, T. P.; McCammon, J. A.; Wlodawer, A. Rational Design of HIV Protease Inhibitors.Structural Biology of Viruses; Chiu, W., Burnett, R. M., Garcea, R. L., Eds.; Oxford University Press:  New York, 1997; pp 451−473.

2. Crystal structures of HIV-1 protease-inhibitor complexes

3. STRUCTURE-BASED INHIBITORS OF HIV-1 PROTEASE

4. HIV-1 protease: mechanism and drug discovery

5. Rational Approach to AIDS Drug Design Through Structural Biology

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