Development of a Multikilogram Synthesis of a Chiral Epoxide Precursor to a CCR1 Antagonist. Use of in Situ Monitoring for Informed Optimisation via Fragile Intermediates-Reference-Cited by-同舟云学术

Development of a Multikilogram Synthesis of a Chiral Epoxide Precursor to a CCR1 Antagonist. Use of in Situ Monitoring for Informed Optimisation via Fragile Intermediates

Published:2009-11-10 Issue:1 Volume:14 Page:72-84
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Ainge Debra¹,Booker James E. M.¹,Pedge Nicholas¹,Sinclair Rhona¹,Sleigh Chris¹,Štefinović Marijan¹,Vaz Luis-Manuel¹,Way Edward¹

Affiliation:

1. Process Research and Development and Medicinal Chemistry, AstraZeneca, Charnwood, Bakewell Road, Loughborough LE11 5RH, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op900172t

Reference38 articles.

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4. Ainge, D.; Gnad, F.; Sinclair, R.; Vaz, L.M.; Wells, A.PCT Int. Appl. CODEN: PIXXD2, WO 2009/035407 A1 2009/0319;32 pages.

5. Ainge, D.; Cornwall, P.; Gill, D.; Vaz, L.M.PCT Int. Appl. CODEN: PIXXD2, WO 2008/010764 A2 2008/0124;41 pages.

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