1. Institute of Chemical and Engineering Sciences, 1 Pesek Road, Jurong Island, S(627833), Singapore, Institute of Organic Chemistry and Biochemistry, Flemingovo n. 2., 166 10 Prague 6, Czech Republic, and Biocatalysis and Organic Chemistry, Delft University of Technology, Julianalaan 136, 2628 BL Delft, The Netherlands ilya.lyapkalo@uochb.cas.cz