Stereoselective Synthesis of 3-Substituted Tetrahydropyrazinoisoquinolines via Intramolecular Cyclization of Enantiomerically Enriched Dihydro-2H-pyrazines-Reference-Cited by-同舟云学术

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Stereoselective Synthesis of 3-Substituted Tetrahydropyrazinoisoquinolines via Intramolecular Cyclization of Enantiomerically Enriched Dihydro-2H-pyrazines

Published:2015-01-28 Issue:3 Volume:17 Page:398-401
ISSN:1523-7060
Container-title:Organic Letters
language:en
Short-container-title:Org. Lett.

Author:

Reginato Gianna¹,Catalani Maria Pia²³,Pezzati Bernardo¹³,Di Fabio Romano²,Bernardelli Andrea²,Curcuruto Ornella²,Moro Elisa²,Pozzan Alfonso²,Mordini Alessandro¹³

Affiliation:

1. ICCOM − CNR, Via Madonna del Piano 1, 50019 Sesto Fiorentino, Italy

2. Aptuit, Drug Design & Discovery, Via A. Fleming 4, 37135 Verona, Italy

3. Dipartimento di Chimica “Ugo Schiff”, University of Florence, Via della Lastruccia 10, 50019 Sesto Fiorentino, Italy

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ol503431f

Reference46 articles.

1. Cardiovascular activity of some substituted 2-aminobenzoquinolizines

2. Synthesis and structure-activity relationships of 2-sulfonamido-1,3,4,6,7,11b.alpha.-hexahydro-2H-benzo[a]quinolizines as .alpha.2-adrenoceptor antagonists

3. (8a.alpha.,12a.alpha.,13a.alpha.)-5,8,8a,9,10,11,12,12a,13,13a,-Decahydro-3-methoxy-12-(methylsulfonyl)-6H-isoquino[2,1-g][1,6]naphthyridine, a potent and highly selective .alpha.2-adrenoceptor antagonist

4. Synthesis and stereochemistry of 7-phenyl-2-propionanilidobenzo[a]quinolizidine derivatives. Structural probes of fentanyl analgesics

5. 1,3-Disubstituted 4-aminopiperidines as useful tools in the optimization of the 2-aminobenzo[a]quinolizine dipeptidyl peptidase IV inhibitors

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1. One‐pot synthesis of novel spirocyclic‐dihydropyrazine‐2‐( 1 H )ones through a Ugi 4‐CR /deprotection;Journal of Heterocyclic Chemistry;2021-12-08

2. Efficient synthesis of 5-(hydroxymethyl)piperazin-2-ones using automatically prepared chiral bromocarboxylic acid and Garner’s aldehyde as versatile building blocks;Bioorganic & Medicinal Chemistry Letters;2021-05

3. Acid-Promoted One-Pot Synthesis of Substituted Furan and 6-Methylpyrazin-2(1H)-one Derivatives via Allene Intermediate Formed in Situ;ACS Combinatorial Science;2018-04-05

4. Synthesis of 6-methyl-3,4-dihydropyrazinones using an Ugi 4-CR/allenamide cycloisomerization protocol;Organic & Biomolecular Chemistry;2017

5. Preparation of Reduced Pyrazino[2,1-a]isoquinoline Derivatives: Important Heterocycles in the Field of Bioactive Compounds;Synthesis;2016-08-16

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