Methodology for the Preparation of Pure Recombinant S. cerevisiae Lanosterol Synthase Using a Baculovirus Expression System. Evidence That Oxirane Cleavage and A-Ring Formation Are Concerted in the Biosynthesis of Lanosterol from 2,3-Oxidosqualene-Reference-Cited by-同舟云学术

Methodology for the Preparation of Pure Recombinant S. cerevisiae Lanosterol Synthase Using a Baculovirus Expression System. Evidence That Oxirane Cleavage and A-Ring Formation Are Concerted in the Biosynthesis of Lanosterol from 2,3-Oxidosqualene

Published:1997-02-01 Issue:6 Volume:119 Page:1277-1288
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Corey E. J.¹,Cheng Hengmiao¹,Baker C. Hunter¹,Matsuda Seiichi P. T.¹,Li Ding¹,Song Xuelei¹

Affiliation:

1. Contribution from the Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/ja963227w

Reference20 articles.

1. Enzymatic cyclization of squalene and oxidosqualene to sterols and triterpenes

2. Cloning and characterization of the 2,3-oxidosqualene cyclase-coding gene of Candida albicans

3. Vectors used: pKK223-3, pLM1, pKen2, pET-15b. Strains used: JM101, XA90, BL21-DE(3), BL21-DE(3)pLysS.

4. 1H and13C NMR assignments for lanostan-3β-ol derivatives: Revised assignments for lanosterol

5. New Insights Regarding the Cyclization Pathway for Sterol Biosynthesis from (S)-2,3-Oxidosqualene

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