Discovery ofN-[(4R)-6-(4-Chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-5-methyl-1H-pyrazole-3-carboxamide (MK-5596) as a Novel Cannabinoid-1 Receptor (CB1R) Inverse Agonist for the Treatment of Obesity-Reference-Cited by-同舟云学术

Discovery ofN-[(4R)-6-(4-Chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-5-methyl-1H-pyrazole-3-carboxamide (MK-5596) as a Novel Cannabinoid-1 Receptor (CB1R) Inverse Agonist for the Treatment of Obesity

Published:2010-05-27 Issue:10 Volume:53 Page:4028-4037
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Yan Lin,Huo Pei,Debenham John S.,Madsen-Duggan Christina B.,Lao Julie,Chen Richard Z.,Xiao Jing Chen,Shen Chun-Pyn,Stribling D. Sloan,Shearman Lauren P.,Strack Alison M.,Tsou Nancy,Ball Richard G.,Wang Junying,Tong Xinchun,Bateman Thomas J.,Reddy Vijay B. G.,Fong Tung M.,Hale Jeffrey J.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm100023j

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