Discovery and Optimization of Potent GPR40 Full Agonists Containing Tricyclic Spirocycles-Reference-Cited by-同舟云学术

Discovery and Optimization of Potent GPR40 Full Agonists Containing Tricyclic Spirocycles

Published:2013-05-13 Issue:6 Volume:4 Page:551-555
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Wang Yingcai¹,Liu Jiwen (Jim)¹,Dransfield Paul J.¹,Zhu Liusheng¹,Wang Zhongyu¹,Du Xiaohui¹,Jiao Xianyun¹,Su Yongli¹,Li An-rong¹,Brown Sean P.¹,Kasparian Annie¹,Vimolratana Marc¹,Yu Ming¹,Pattaropong Vatee¹,Houze Jonathan B.¹,Swaminath Gayathri¹,Tran Thanhvien¹,Nguyen Khanh¹,Guo Qi¹,Zhang Jane¹,Zhuang Run¹,Li Frank¹,Miao Lynn¹,Bartberger Michael D.¹,Correll Tiffany L.¹,Chow David¹,Wong Simon¹,Luo Jian¹,Lin Daniel C.-H.¹,Medina Julio C.¹

Affiliation:

1. Department of Therapeutic Discovery, Metabolic Disorders, Translational Sciences, Amgen Inc., 1120 Veterans Boulevard, South San Francisco, California 94080, United States and One Amgen Center Drive, Thousand Oaks, California 91320, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ml300427u

Reference28 articles.

1. From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus

2. Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40

3. International Union of Pharmacology. LXXI. Free Fatty Acid Receptors FFA1, -2, and -3: Pharmacology and Pathophysiological Functions

4. Progress in the discovery and development of small-molecule modulators of G-protein-coupled receptor 40 (GPR40/FFA1/FFAR1): an emerging target for type 2 diabetes

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