Diastereoselective Syntheses of (3R*,4R*)- and (3R*,4S*)-4-Aryl-3-methyl-4-piperidinemethanol and Fluoro Analogues

Author:

Schmitt Sébastien123,Brown Richard C. D.4,Perrio Cécile123

Affiliation:

1. CNRS, UMR 6301 ISTCT, LDM − TEP, GIP Cyceron, Boulevard Henri Becquerel, BP5229, F-14074 Caen Cedex, France

2. Université de Caen Basse-Normandie, UMR 6301 ISTCT, LDM − TEP, GIP Cyceron, Boulevard Henri Becquerel, BP5229, F-14074 Caen Cedex, France

3. CEA, DSV/I2BM, UMR 6301 ISTCT, LDM − TEP, GIP Cyceron, Boulevard Henri Becquerel, BP5229, F-14074 Caen Cedex, France

4. School of Chemistry, University of Southampton, Highfield, Southampton SO17 1BJ, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Reference47 articles.

1. Cid-Nunez, J. M.; Trabanco-Suarez, A. A.; McDonald, G. J.; Duvey, G. A. J.; Lutjens, R. J.PCT WO2008/107479, September 12, 2008.

2. Schmitz, W. D.; Whitney, I. E.; Degnan, A. P.; Bronson, J. J.PCT WO2009/009633, Jan 15, 2009.

3. Budzik, B. W.; Haile, P. A.; Hughes, T. V.; Sehon, C. A.; Wang, G. Z.PCT WO2009/061881, May 14, 2009.

4. A new synthesis of spiropyrrolidine–tetralones via an unexpected formal ring-contraction of 4-disubstituted piperidine to 3-disubstituted pyrrolidine

5. Exploration of the Amine Terminus in a Novel Series of 1,2,4-Triazolo-3-yl-azabicyclo[3.1.0]hexanes as Selective Dopamine D3 Receptor Antagonists

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