Inhibitor of Ovarian Cancer Cells Growth by Virtual Screening: A New Thiazole Derivative Targeting Human Thymidylate Synthase-Reference-Cited by-同舟云学术

Inhibitor of Ovarian Cancer Cells Growth by Virtual Screening: A New Thiazole Derivative Targeting Human Thymidylate Synthase

Published:2012-11-05 Issue:22 Volume:55 Page:10272-10276
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Carosati Emanuele¹,Tochowicz Anna²,Marverti Gaetano³,Guaitoli Giambattista⁴,Benedetti Paolo⁵,Ferrari Stefania⁴,Stroud Robert M.²,Finer-Moore Janet²,Luciani Rosaria⁴,Farina Davide⁴,Cruciani Gabriele¹,Costi M. Paola⁴

Affiliation:

1. Dipartimento di Chimica, Università degli Studi di Perugia, Via Elce di Sotto 10, 06123, Perugia, Italy

2. Department of Biochemistry and Biophysics, University of California—San Francisco, 600 16th Street, San Francisco 94158, California, United States

3. Dipartimento di Scienze Biomediche, Metaboliche e Neuroscienze, Università degli Studi di Modena e Reggio Emilia, Via Campi 287, 41125 Modena, Italy

4. Dipartimento di Scienze Farmaceutiche, Università degli Studi di Modena e Reggio Emilia, Via Campi 183, 41125 Modena, Italy

5. Molecular Discovery Limited, 215 Marsh Road, Pinner, Middlesex, London HA5 5NE, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm300850v

Reference25 articles.

1. THE CATALYTIC MECHANISM AND STRUCTURE OF THYMIDYLATE SYNTHASE

2. Conformational Dynamics along an Enzymatic Reaction Pathway: Thymidylate Synthase, “the Movie”

3. Lessons and Conclusions from Dissecting the Mechanism of a Bisubstrate Enzyme: Thymidylate Synthase Mutagenesis, Function, and Structure