Stereoselective Construction of the 5-Hydroxy Diazabicyclo[4.3.1]decane-2-one Scaffold, a Privileged Motif for FK506-Binding Proteins
Author:
Affiliation:
1. Max Planck Institute of Psychiatry, Kraepelinstr. 2, 80804 München, Germany
2. Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
Funder
Munich Biotech Cluster m4
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/ol5023195
Reference26 articles.
1. A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin
2. A receptor for the immuno-suppressant FK506 is a cis–trans peptidyl-prolyl isomerase
3. Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast
4. Comparative Analysis of Calcineurin Inhibition by Complexes of Immunosuppressive Drugs with Human FK506 Binding Proteins
5. Large FK506-Binding Proteins Shape the Pharmacology of Rapamycin
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