Highly Enantioselective Reduction of a Small Heterocyclic Ketone: Biocatalytic Reduction of Tetrahydrothiophene-3-one to the Corresponding (R)-Alcohol-Reference-Cited by-同舟云学术

Highly Enantioselective Reduction of a Small Heterocyclic Ketone: Biocatalytic Reduction of Tetrahydrothiophene-3-one to the Corresponding (R)-Alcohol

Published:2009-12-01 Issue:1 Volume:14 Page:188-192
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Liang Jack¹,Mundorff Emily¹,Voladri Rama¹,Jenne Stephan¹,Gilson Lynne¹,Conway Aaron¹,Krebber Anke¹,Wong John¹,Huisman Gjalt¹,Truesdell Susan¹,Lalonde James¹

Affiliation:

1. Codexis, Inc., 200 Penobscot Drive, Redwood City, California 94063, U.S.A., and Pfizer Global R&D, Easten Point Road, Groton, Connecticut 06340, U.S.A.

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op9002714

Reference56 articles.

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2. 2-Thioalkyl penems: an efficient synthesis of sulopenem, a (5R,6S)-6-(1(R)-hydroxyethyl)-2-[(cis-1-oxo-3-thiolanyl)thio]-2-penem antibacterial

3. The (S)-alcohol has been prepared in five steps from (S)-dimethyl malate in ∼11% overall yield and involves LAH in Et2O, Li2S, protection/deprotection and chromagraphic purification.

4. Cyclic sulfolanes as novel and high-affinity P2 ligands for HIV-1 protease inhibitors

5. The Development of Cyclic Sulfolanes as Novel and High-Affinity P2 Ligands for HIV-1 Protease Inhibitors

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