Role of a Guanidinium Cation–Phosphodianion Pair in Stabilizing the Vinyl Carbanion Intermediate of Orotidine 5′-Phosphate Decarboxylase-Catalyzed Reactions-Reference-Cited by-同舟云学术

Role of a Guanidinium Cation–Phosphodianion Pair in Stabilizing the Vinyl Carbanion Intermediate of Orotidine 5′-Phosphate Decarboxylase-Catalyzed Reactions

Published:2013-10-08 Issue:42 Volume:52 Page:7500-7511
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Goryanova Bogdana¹,Goldman Lawrence M.¹,Amyes Tina L.¹,Gerlt John A.²,Richard John P.¹

Affiliation:

1. Department of Chemistry, University at Buffalo, Buffalo, New York 14260, United States

2. Department of Biochemistry and Chemistry, University of Illinois, Urbana, Illinois 61801, United States

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/bi401117y

Reference60 articles.

1. A Proficient Enzyme

2. Anatomy of a proficient enzyme: The structure of orotidine 5'-monophosphate decarboxylase in the presence and absence of a potential transition state analog

3. Equilibrium of Formation of the 6-Carbanion of UMP, a Potential Intermediate in the Action of OMP Decarboxylase

4. Stability of the 6-Carbanion of Uracil Analogues: Mechanistic Implications for Model Reactions of Orotidine-5‘-monophosphate Decarboxylase

5. Inhibition of orotidine-5'-phosphate decarboxylase by 1-(5'-phospho-.beta.-D-ribofuranosyl)barbituric acid, 6-azauridine 5'-phosphate, and uridine 5'-phosphate

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