Chiral Sulfoxides as Metabolites of 2-Thioimidazole-Based p38α Mitogen-Activated Protein Kinase Inhibitors: Enantioselective Synthesis and Biological Evaluation-Reference-Cited by-同舟云学术

Chiral Sulfoxides as Metabolites of 2-Thioimidazole-Based p38α Mitogen-Activated Protein Kinase Inhibitors: Enantioselective Synthesis and Biological Evaluation

Published:2011-04-12 Issue:9 Volume:54 Page:3283-3297
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Bühler Stefanie¹,Goettert Marcia¹,Schollmeyer Dieter²,Albrecht Wolfgang³,Laufer Stefan A.¹

Affiliation:

1. Department of Pharmaceutical/Medicinal Chemistry, Eberhard-Karls-University Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany

2. Institute of Organic Chemistry, University Mainz, Duesbergweg 10-14, 55099 Mainz, Germany

3. c-a-i-r biosciences GmbH, Paul-Ehrlich-Strasse 15, 72076 Tübingen, Germany

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm101623p

Reference50 articles.

1. Protein Kinases as Small Molecule Inhibitor Targets in Inflammation

2. Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways

3. Rational design of inhibitors that bind to inactive kinase conformations

4. MAP Kinases

5. The Biology of p38 Kinase: A Central Role in Inflammation

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