An Improved Preparation of 3,5-Bis(trifluoromethyl)acetophenone and Safety Considerations in the Preparation of 3,5-Bis(trifluoromethyl)phenyl Grignard Reagent-Reference-Cited by-同舟云学术

An Improved Preparation of 3,5-Bis(trifluoromethyl)acetophenone and Safety Considerations in the Preparation of 3,5-Bis(trifluoromethyl)phenyl Grignard Reagent

Published:2003-04-09 Issue:9 Volume:68 Page:3695-3698
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Leazer, Johnnie L.¹,Cvetovich Raymond¹,Tsay Fuh-Rong¹,Dolling Ulf¹,Vickery Thomas¹,Bachert Donald¹

Affiliation:

1. Department of Process Research and Department of Chemical and Engineering Research and Development, Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065 %john_leazer@merck.com

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/jo026903n

Reference33 articles.

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2. Practical Asymmetric Synthesis of Aprepitant, a Potent Human NK-1 Receptor Antagonist, via a Stereoselective Lewis Acid-Catalyzed Trans Acetalization Reaction

3. Crystallization-Induced Diastereoselection: Asymmetric Synthesis of Substance P Inhibitors

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