Multivalent N-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing-Reference-Cited by-同舟云学术

Multivalent N-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing

Published:2014-12-01 Issue:49 Volume:136 Page:16958-16961
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Nair Jayaprakash K.¹,Willoughby Jennifer L. S.¹,Chan Amy¹,Charisse Klaus¹,Alam Md. Rowshon¹,Wang Qianfan¹,Hoekstra Menno²,Kandasamy Pachamuthu¹,Kel’in Alexander V.¹,Milstein Stuart¹,Taneja Nate¹,O’Shea Jonathan¹,Shaikh Sarfraz¹,Zhang Ligang¹,van der Sluis Ronald J.²,Jung Michael E.³,Akinc Akin¹,Hutabarat Renta¹,Kuchimanchi Satya¹,Fitzgerald Kevin¹,Zimmermann Tracy¹,van Berkel Theo J. C.²,Maier Martin A.¹,Rajeev Kallanthottathil G.¹,Manoharan Muthiah¹

Affiliation:

1. Alnylam Pharmaceuticals, 300 Third Street, Cambridge, Massachusetts 02142, United States

2. Division of Biopharmaceutics, Leiden Academic Center for Drug Research, 2300 RA Leiden, The Netherlands

3. Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, United States

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/ja505986a

Reference27 articles.

1. RNAi therapeutics: a potential new class of pharmaceutical drugs