Probing Chemical Equilibrium in Frozen Sodium Phosphate Buffer Solution by <sup>31</sup>P Solid-State NMR-Reference-Cited by-同舟云学术

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Probing Chemical Equilibrium in Frozen Sodium Phosphate Buffer Solution by ³¹P Solid-State NMR

Published:2024-05-20 Issue:21 Volume:15 Page:5714-5720
ISSN:1948-7185
Container-title:The Journal of Physical Chemistry Letters
language:en
Short-container-title:J. Phys. Chem. Lett.

Author:

Du Yong¹^ORCID,Li Jinghan²^ORCID,Suryanarayanan Raj²^ORCID,Su Yongchao¹³^ORCID

Affiliation:

1. Analytical Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States

2. Department of Pharmaceutics College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, United States

3. Pharmaceutical Sciences and Clinical Supply, Merck & Co., Inc., West Point, Pennsylvania 19486, United States

Funder

University of Minnesota

Merck

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jpclett.4c00877

Reference26 articles.

1. Freezing of Biologicals Revisited: Scale, Stability, Excipients, and Degradation Stresses

2. Protein Stability During Freezing: Separation of Stresses and Mechanisms of Protein Stabilization

3. Freezing-induced protein aggregation - Role of pH shift and potential mitigation strategies

4. Characterization of Phosphate Buffered Saline (PBS) in Frozen State and after Freeze-Drying

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