A Switch between Two Intrinsically Disordered Conformational Ensembles Modulates the Active Site of a Basic-Helix–Loop–Helix Transcription Factor-Reference-Cited by-同舟云学术

A Switch between Two Intrinsically Disordered Conformational Ensembles Modulates the Active Site of a Basic-Helix–Loop–Helix Transcription Factor

Published:2020-10-08 Issue:21 Volume:11 Page:8944-8951
ISSN:1948-7185
Container-title:The Journal of Physical Chemistry Letters
language:en
Short-container-title:J. Phys. Chem. Lett.

Author:

Sicoli Giuseppe¹^ORCID,Kress Thomas²^ORCID,Vezin Hervé¹,Ledolter Karin³,Kurzbach Dennis⁴^ORCID

Affiliation:

1. Laboratoire Avancé de Spectroscopie pour les Interactions, la Réactivité et l’Environnement (LASIRE), UMR CNRS 8516, Université de Lille, Avenue Paul Langevin − C4, F-59655 Villeneuve d’Ascq, France

2. Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K.

3. Department for Structural and Computational Biology, Max F. Perutz Laboratories, University Vienna, Campus Vienna BioCenter 5, 1030 Vienna, Austria

4. Faculty of Chemistry, Institute of Biological Chemistry, University of Vienna, Währinger Str. 38, 1090 Vienna, Austria

Funder

H2020 European Research Council

Publisher

American Chemical Society (ACS)

Subject

General Materials Science,Physical and Theoretical Chemistry

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.jpclett.0c02242

Reference42 articles.

1. The Human Transcription Factors

2. Structural Dynamics, Intrinsic Disorder, and Allostery in Nuclear Receptors as Transcription Factors