1. Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan, Medical College of Georgia, Augusta, Georgia 30912, St. Marianna University, School of Medicine, Miyamae-ku, Kawasaki 216-8511, Japan, James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky 40202, and Tokyo Medical and Dental University, School of Medicine, Bunkyo-ku, Tokyo 113-8519, Japan