Synthesis and Biological Evaluation of 7,8,9,10-Tetrahydroimidazo[1,2-c]pyrido[3,4-e]pyrimdin-5(6H)-ones as Functionally Selective Ligands of the Benzodiazepine Receptor Site on the GABAA Receptor-Reference-Cited by-同舟云学术

Synthesis and Biological Evaluation of 7,8,9,10-Tetrahydroimidazo[1,2-c]pyrido[3,4-e]pyrimdin-5(6H)-ones as Functionally Selective Ligands of the Benzodiazepine Receptor Site on the GABAA Receptor

Published:2002-10-15 Issue:23 Volume:45 Page:5043-5051
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Albaugh Pamela A.¹,Marshall Lu¹,Gregory James¹,White Geoff¹,Hutchison Alan¹,Ross Phil C.¹,Gallagher Dorothy W.¹,Tallman John F.¹,Crago Matt¹,Cassella James V.¹

Affiliation:

1. Neurogen Corporation, 35 Northeast Industrial Road, Branford, Connecticut 06405

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0202019

Reference18 articles.

1. Resolution of two biochemically and pharmacologically distinct benzodiazepine receptors

2. Thienylpyrazoloquinolines with high affinity to benzodiazepine receptors: continuous shift from inverse agonist to agonist properties depending on the size of the alkyl substituent

3. Synthesis and evaluation of a series of aryl[e]fused pyrazolo[4,3-c]pyridines with potential anxiolytic activity

Cited by 39 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Treating Aggressive Behavior in Psychiatric Inpatients: The Efficacy of Different GABAergic Agents, Benzodiazepines, and Z Drugs;Handbook of Anger, Aggression, and Violence;2023

2. Pyrazole-containing pharmaceuticals: target, pharmacological activity, and their SAR studies;RSC Medicinal Chemistry;2022

3. Treating Aggressive Behavior in Psychiatric Inpatients: The Efficacy of Different GABAergic Agents, Benzodiazepines, and Z Drugs;Handbook of Anger, Aggression, and Violence;2022

4. THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels;British Journal of Pharmacology;2021-09-16

5. Prescribed drugs containing nitrogen heterocycles: an overview;RSC Advances;2020