Improved Extrapolation of Hepatobiliary Clearance from in Vitro Sandwich Cultured Rat Hepatocytes through Absolute Quantification of Hepatobiliary Transporters-Reference-Cited by-同舟云学术

Improved Extrapolation of Hepatobiliary Clearance from in Vitro Sandwich Cultured Rat Hepatocytes through Absolute Quantification of Hepatobiliary Transporters

Published:2010-05-13 Issue:3 Volume:7 Page:630-641
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Li Na¹,Singh Pratap¹,Mandrell Kathy M.¹,Lai Yurong¹

Affiliation:

1. Department of Pharmacokinetics, Dynamics, and Drug Metabolism, Pfizer Global Research & Development, Pfizer Inc, Groton, Connecticut 06340

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/mp9001574

Reference48 articles.

1. In Vitro Biliary Clearance of Angiotensin II Receptor Blockers and 3-Hydroxy-3-methylglutaryl-Coenzyme A Reductase Inhibitors in Sandwich-Cultured Rat Hepatocytes: Comparison with in Vivo Biliary Clearance

2. Obach, R. S.In vitro drug metabolism information in the prediction of human pharmacokinetics. InPharmacokinetics in Drug Development: Clinical Study Design and Analysis;Bonate, P.; Howard, D., Eds.Springer:New York, 2004; Vol.1, pp445−78.

3. QUANTITATIVE PREDICTION OF IN VIVO DRUG CLEARANCE AND DRUG INTERACTIONS FROM IN VITRO DATA ON METABOLISM, TOGETHER WITH BINDING AND TRANSPORT

4. Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data

5. Transporters for Bile Acids and Organic Anions

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