Design of High-Throughput Screening Assays and Identification of a SUMO1-Specific Small Molecule Chemotype Targeting the SUMO-Interacting Motif-Binding Surface-Reference-Cited by-同舟云学术

Design of High-Throughput Screening Assays and Identification of a SUMO1-Specific Small Molecule Chemotype Targeting the SUMO-Interacting Motif-Binding Surface

Published:2015-03-23 Issue:4 Volume:17 Page:239-246
ISSN:2156-8952
Container-title:ACS Combinatorial Science
language:en
Short-container-title:ACS Comb. Sci.

Author:

Alontaga Aileen Y.¹,Li Yifei¹,Chen Chih-Hong¹,Ma Chen-Ting²,Malany Siobhan³,Key Danielle E.³,Sergienko Eduard²,Sun Qing²,Whipple David A.⁴,Matharu Daljit S.⁴,Li Baozong¹,Vega Ramir¹,Li Yi-Jia¹,Schoenen Frank J.⁴,Blagg Brian S. J.⁴,Chung Thomas D.Y.²,Chen Yuan¹

Affiliation:

1. Department of Molecular Medicine, Beckman Research Institute of the City of Hope, Duarte, California 91010, United States

2. Conrad Prebys Center for Chemical Genomics, Sanford-Burnham Institute, La Jolla, California 92037, United States

3. Conrad Prebys Center for Chemical Genomics, Sanford-Burnham Institute at Lake Nona, Orlando, Florida 32827, United States

4. University of Kansas Specialized Chemistry Center, Lawrence, Kansas 66049, United States

Publisher

American Chemical Society (ACS)

Subject

General Chemistry,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/co500181b

Reference24 articles.

1. A SUMOylation-Dependent Transcriptional Subprogram Is Required for Myc-Driven Tumorigenesis

2. Functional genomics identifies therapeutic targets for MYC-driven cancer

3. Role of SUMO:SIM-mediated protein–protein interaction in non-homologous end joining

4. Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks

5. Rhes, a Striatal Specific Protein, Mediates Mutant-Huntingtin Cytotoxicity

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