Identification of Differential Protein Binding Affinities in an Atropisomeric Pharmaceutical Compound by Noncovalent Mass Spectrometry, Equilibrium Dialysis, and Nuclear Magnetic Resonance-Reference-Cited by-同舟云学术

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Identification of Differential Protein Binding Affinities in an Atropisomeric Pharmaceutical Compound by Noncovalent Mass Spectrometry, Equilibrium Dialysis, and Nuclear Magnetic Resonance

Published:2013-06-03 Issue:12 Volume:85 Page:5958-5964
ISSN:0003-2700
Container-title:Analytical Chemistry
language:en
Short-container-title:Anal. Chem.

Author:

Maple Hannah J.¹²,Garlish Rachel A.²,Whitcombe Ian²,Hold Adam³,Prosser Christine E.²,Ford Daniel²,Mackenzie Harry²,Crosby John¹,Porter John²,Taylor Richard J.²,Crump Matthew P.¹

Affiliation:

1. School of Chemistry, University of Bristol, Cantock’s Close, Clifton, Bristol BS8 1TS, United Kingdom

2. UCB Pharma, 216 Bath Road, Slough, Berkshire SL1 4EN, United Kingdom

3. LC/MS Consulting Limited, St. Albans, Hertfordshire AL1 3BZ, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Analytical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ac400760p

Reference20 articles.

1. The Challenge of Atropisomerism in Drug Discovery

2. Design and optimization of cyclized NK1 antagonists with controlled atropisomeric properties

3. Enantiomerization of an atropisomeric drug

4. Apoptosis in the Pathogenesis and Treatment of Disease

5. Programmed cell death: alive and well in the new millennium

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1. Sample preparation techniques for protein binding measurement in radiopharmaceutical approaches: A short review;Talanta;2020-11

2. Stepwise frontal affinity chromatography model for drug and protein interaction;Analytical and Bioanalytical Chemistry;2018-07-02

3. Synthesis, characterisation and dynamic behavior of photoactive bipyridyl ruthenium(II)-nicotinamide complexes;Inorganica Chimica Acta;2017-01

4. DNA Oligonucleotides: A Model System with Tunable Binding Strength to Study Monomer–Dimer Equilibria with Electrospray Ionization-Mass Spectrometry;Analytical Chemistry;2013-11-26

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