1. Department of Pharmaceutical Chemistry, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, New Jersey 08854; Enact Pharma PLC, Porton Down Science Park, Salisbury, Wiltshire, SP4 0JQ, UK; and University of Birmingham, Edgbaston, Birmingham B15 2TT, UK