Hydrophilic, Pro-Drug Analogues of T138067 Are Efficacious in Controlling Tumor Growth In Vivo and Show a Decreased Ability To Cross the Blood Brain Barrier-Reference-Cited by-同舟云学术

Hydrophilic, Pro-Drug Analogues of T138067 Are Efficacious in Controlling Tumor Growth In Vivo and Show a Decreased Ability To Cross the Blood Brain Barrier

Published:2001-09-14 Issue:22 Volume:44 Page:3599-3605
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Rubenstein Steven M.¹,Baichwal Vijay¹,Beckmann Holger¹,Clark David L.¹,Frankmoelle Walter¹,Roche Daniel¹,Santha Edit¹,Schwender Susan¹,Thoolen Martin¹,Ye Qiuping¹,Jaen Juan C.¹

Affiliation:

1. Tularik Inc., Two Corporate Drive, South San Francisco, California 94080

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm000478d

Reference12 articles.

1. The clinical pharmacology and use of antimicrotubule agents in cancer chemotherapeutics

2. Selective, covalent modification of -tubulin residue Cys-239 by T138067, an antitumor agent with in vivo efficacy against multidrug-resistant tumors

3. Novel halogenated sulfonamides inhibit the growth of multidrug resistant MCF-7/ADR cancer cells

4. Novel antineoplastic agents with efficacy against multidrug resistant tumor cells

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