Stereocontrolled Disruption of the Ugi Reaction toward the Production of Chiral Piperazinones: Substrate Scope and Process Development-Reference-Cited by-同舟云学术

Stereocontrolled Disruption of the Ugi Reaction toward the Production of Chiral Piperazinones: Substrate Scope and Process Development

Published:2014-10-22 Issue:21 Volume:79 Page:9948-9957
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Zaretsky Serge¹,Adachi Shinya¹,Rotstein Benjamin H.¹,Hickey Jennifer L.²,Scully Conor C. G.¹,St. Denis Jeffrey D.¹,Courtemanche Rebecca¹,Yu Joy C. Y.¹,Chung Benjamin K. W.¹,Yudin Andrei K.¹

Affiliation:

1. Davenport Research Laboratories, Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 3H6, Canada

2. Encycle Therapeutics, Inc., 101 College Street, Suite 314, Toronto, Ontario M5G 1L7, Canada

Funder

Natural Sciences and Engineering Research Council of Canada

Ontario Genomics Institute

Québec Consortium for Drug Discovery

Canadian Foundation for Innovation

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/jo5018316

Reference44 articles.

1. Strategies for Innovation in Multicomponent Reaction Design

2. “Multi-component Reactions : Emerging Chemistry in Drug Discovery” ‘From Xylocain to Crixivan’

3. Catalytic Ugi-Type Condensation of α-Isocyanoacetamide and Chiral Cyclic Imine: Access to Asymmetric Construction of Several Heterocycles

4. Chemistry and Biology Of Multicomponent Reactions

5. Discovery of a Novel Class of Potent HCV NS4B Inhibitors: SAR Studies on Piperazinone Derivatives

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