Phosphoramidate ProTides of the Anticancer Agent FUDR Successfully Deliver the Preformed Bioactive Monophosphate in Cells and Confer Advantage over the Parent Nucleoside-Reference-Cited by-同舟云学术

Phosphoramidate ProTides of the Anticancer Agent FUDR Successfully Deliver the Preformed Bioactive Monophosphate in Cells and Confer Advantage over the Parent Nucleoside

Published:2011-09-27 Issue:20 Volume:54 Page:7247-7258
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

McGuigan Christopher¹,Murziani Paola¹,Slusarczyk Magdalena¹,Gonczy Blanka¹,Vande Voorde Johan²,Liekens Sandra²,Balzarini Jan²

Affiliation:

1. Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF10 3NB, U.K.

2. Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, Leuven B-3000, Belgium

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm200815w

Reference30 articles.

1. Fluorinated Pyrimidines, A New Class of Tumour-Inhibitory Compounds

2. Hepatic Arterial Infusion of Chemotherapy for Hepatic Metastases from Colorectal Cancer

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4. 5-Fluorouracil: mechanisms of action and clinical strategies

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