Reaction Mechanism of N-Acetylneuraminic Acid Lyase Revealed by a Combination of Crystallography, QM/MM Simulation, and Mutagenesis-Reference-Cited by-同舟云学术

Reaction Mechanism of N-Acetylneuraminic Acid Lyase Revealed by a Combination of Crystallography, QM/MM Simulation, and Mutagenesis

Published:2014-02-21 Issue:4 Volume:9 Page:1025-1032
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Daniels Adam D.¹,Campeotto Ivan¹,van der Kamp Marc W.²,Bolt Amanda H.¹,Trinh Chi H.¹,Phillips Simon E. V.¹,Pearson Arwen R.¹,Nelson Adam³,Mulholland Adrian J.²,Berry Alan¹

Affiliation:

1. Astbury Centre for Structural Molecular Biology and School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, U.K.

2. Centre for Computational Chemistry, School of Chemistry, University of Bristol, Bristol BS8 1TS, U.K.

3. Astbury Centre for Structural Molecular Biology and School of Chemistry, University of Leeds, Leeds LS2 9JT, U.K.

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/cb500067z

Reference32 articles.

1. Directed evolution of aldolases for exploitation in synthetic organic chemistry

2. Purification and Properties of N-Acetylneuraminate Lyase from Escherichia coli1

3. Mechanistic model for the synthesis of N-acetylneuraminic acid using N-acetylneuraminate lyase from Escherichia coli K12

4. Active site modulation in the N-acetylneuraminate lyase sub-family as revealed by the structure of the inhibitor-complexed Haemophilus influenzae enzyme

5. Structural Insights into Substrate Specificity in Variants of N-Acetylneuraminic Acid Lyase Produced by Directed Evolution

Cited by 42 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Complete Computational Reaction Mechanism for Foldamer-Catalyzed Aldol Condensation;ACS Catalysis;2024-05-01

2. One-pot biosynthesis of N-acetylneuraminic acid from chitin via combination of chitin-degrading enzymes, N-acetylglucosamine-2-epimerase, and N-neuraminic acid aldolase;Frontiers in Microbiology;2023-03-21

3. Biochemical and structural basis of sialic acid utilization by gut microbes;Journal of Biological Chemistry;2023-03

4. A mutagenic analysis of NahE, a hydratase-aldolase in the naphthalene degradative pathway;Archives of Biochemistry and Biophysics;2023-01

5. Structurally Informed Mutagenesis of a Stereochemically Promiscuous Aldolase Produces Mutants That Catalyze the Diastereoselective Syntheses of All Four Stereoisomers of 3-Deoxy-hexulosonic Acid;ACS Catalysis;2022-09-06