1. MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Ashton Street, Liverpool L69 3GE, U.K.
2. Otsuka Pharmaceutical Development & Commercialization, Inc., Research Boulevard, Rockville, Maryland 20882, United States
3. Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, Chapel Hill, North Carolina 27599, United States