Effects of GSTT1 Genotype on the Detoxification of 1,3-Butadiene Derived Diepoxide and Formation of Promutagenic DNA–DNA Cross-Links in Human Hapmap Cell Lines

Author:

Boysen Gunnar123ORCID,Arora Rashi4,Degner Amanda14,Vevang Karin R5,Chao Christopher1,Rodriguez Freddys1,Walmsley Scott J.46ORCID,Erber Luke1,Tretyakova Natalia Y.14ORCID,Peterson Lisa A.45ORCID

Affiliation:

1. Department of Medicinal Chemistry, University of Minnesota Minneapolis, Minnesota 55455, United States

2. Department of Environmental and Occupational Health, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, United States

3. The Winthrop P Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, United States

4. University of Minnesota Masonic Cancer Center, Minneapolis, Minnesota 55455, United States

5. Division of Environmental Health Sciences, University of Minnesota, Minneapolis, Minnesota 55455, United States

6. Institute for Health Informatics, University of Minnesota, Minneapolis, Minnesota 55455, United States

Funder

U.S. Department of Health and Human Services

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Reference64 articles.

1. Cancer statistics, 2019

2. American Cancer Society. American Cancer Society Facts & Figures 2019, https://www.cancer.org/research/cancer-facts-statistics/all-cancer-facts-figures/cancer-facts-figures-2019.html# (accessed August 10th, 2020).

3. The Chemical Components of Tobacco and Tobacco Smoke

4. 1,3-Butadiene: III. Assessing carcinogenic modes of action

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