Treatment of Organophosphorus Poisoning with 6-Alkoxypyridin-3-ol Quinone Methide Precursors: Resurrection of Methylphosphonate-Aged Acetylcholinesterase-Reference-Cited by-同舟云学术

Treatment of Organophosphorus Poisoning with 6-Alkoxypyridin-3-ol Quinone Methide Precursors: Resurrection of Methylphosphonate-Aged Acetylcholinesterase

Published:2024-04-01 Issue:4 Volume:37 Page:643-657
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Clay William K.¹^ORCID,Buck Anne K.¹,He Yiran¹^ORCID,Hernández Sánchez Dalyanne N.¹,Ward Nathan A.¹,Lear Jeremy M.¹,Nguyen Kenny Q.¹,Clark Benjamin H.¹,Sapia Ryan J.¹,Lalisse Remy F.¹,Sriraman Aishwarya²³^ORCID,Cadieux C. Linn³,McElroy Craig A.⁴^ORCID,Callam Christopher S.¹^ORCID,Hadad Christopher M.¹^ORCID

Affiliation:

1. Department of Chemistry and Biochemistry, College of Arts and Sciences, The Ohio State University, Columbus, Ohio 43210, United States

2. Oak Ridge Institute for Science and Education, 1299 Bethel Valley Road, Oak Ridge, Tennessee 37830, United States

3. U.S. Army Medical Research Institute of Chemical Defense, 8350 Ricketts Point Road, Aberdeen Proving Ground, Maryland 21010, United States

4. Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States

Funder

National Institute of Neurological Disorders and Stroke

Ohio State University

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.chemrestox.4c00024

Reference89 articles.

1. Why is Aged Acetylcholinesterase So Difficult to Reactivate?

2. Acute toxicity of some nerve agents and pesticides in rats

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