Metabolomics Simultaneously Derives Benchmark Dose Estimates and Discovers Metabolic Biotransformations in a Rat Bioassay-Reference-Cited by-同舟云学术

Metabolomics Simultaneously Derives Benchmark Dose Estimates and Discovers Metabolic Biotransformations in a Rat Bioassay

Published:2024-06-06 Issue:6 Volume:37 Page:923-934
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Sostare Elena¹^ORCID,Bowen Tara J.²,Lawson Thomas N.¹^ORCID,Freier Anne²,Li Xiaojing²^ORCID,Lloyd Gavin R.³,Najdekr Lukáš³^ORCID,Jankevics Andris³^ORCID,Smith Thomas³,Varshavi Dorsa³,Ludwig Christian³,Colbourne John K.¹²,Weber Ralf J. M.¹²³,Crizer David M.⁴,Auerbach Scott S.⁴,Bucher John R.⁴,Viant Mark R.¹²³^ORCID

Affiliation:

1. Michabo Health Science Ltd., Union House, 111 New Union Street, Coventry CV1 2NT, U.K.

2. School of Biosciences, University of Birmingham, Birmingham B15 2TT, U.K.

3. Phenome Centre Birmingham, University of Birmingham, Birmingham B15 2TT, U.K.

4. Division of Translational Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park NC 27709, North Carolina, United States

Funder

National Institute of Environmental Health Sciences

Medical Research Council

Biotechnology and Biological Sciences Research Council

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.chemrestox.4c00002

Reference55 articles.

1. Introduction to benchmark dose methods and U.S. EPA's benchmark dose software (BMDS) version 2.1.1

3. Current modeling practice may lead to falsely high benchmark dose estimates

4. The benchmark dose estimation of reference levels of serum urate for gout