Tyrosinase-Catalyzed Oxidation of the Leukoderma-Inducing Agent Raspberry Ketone Produces (E)-4-(3-Oxo-1-butenyl)-1,2-benzoquinone: Implications for Melanocyte Toxicity
Author:
Affiliation:
1. Department of Chemistry, Fujita Health University School of Health Sciences, Toyoake, Aichi 470-1192, Japan
2. Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan
Funder
Japan Society for the Promotion of Science
Ministry of Health, Labour and Welfare
Publisher
American Chemical Society (ACS)
Subject
Toxicology,General Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.chemrestox.7b00006
Reference49 articles.
1. Chemistry of Mixed Melanogenesis—Pivotal Roles of Dopaquinone
2. Tyrosinase: The four oxidation states of the active site and their relevance to enzymatic activation, oxidation and inactivation
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4. The haptenation theory of vitiligo and melanoma rejection: a close-up
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