Computationally Assessing the Bioactivation of Drugs by N-Dealkylation-Reference-Cited by-同舟云学术

Computationally Assessing the Bioactivation of Drugs by N-Dealkylation

Published:2018-02-06 Issue:2 Volume:31 Page:68-80
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Dang Na Le¹,Hughes Tyler B.¹^ORCID,Miller Grover P.²,Swamidass S. Joshua¹^ORCID

Affiliation:

1. Department of Pathology and Immunology, Washington University School of Medicine, Campus Box 8118, 660 S. Euclid Ave., St. Louis, Missouri 63110, United States

2. Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, United States

Funder

U.S. Department of Health and Human Services

Center for Biological Systems Engineering, Washington University in St. Louis

Department of Immunology and Pathology, Washington University School of Medicine in St. Louis

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.chemrestox.7b00191

Reference59 articles.

1. Radical cation intermediates in N-dealkylation reactions

2. Analysis of Morphine and its Major Metabolites by Differential Radioimmunoassay

3. Norfluoxetine Enantiomers as Inhibitors of Serotonin Uptake in Rat Brain

4. Pharmacokinetics of selective serotonin reuptake inhibitors

5. Modeling Reactivity to Biological Macromolecules with a Deep Multitask Network

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