Comparative Toxicity and Metabolism of N-Acyl Homologues of Acetaminophen and Its Isomer 3′-Hydroxyacetanilide-Reference-Cited by-同舟云学术

Comparative Toxicity and Metabolism of N-Acyl Homologues of Acetaminophen and Its Isomer 3′-Hydroxyacetanilide

Published:2016-10-13 Issue:11 Volume:29 Page:1857-1864
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Koen Yakov M.¹,Liu Ke¹,Shinogle Heather¹,Williams Todd D.¹,Hanzlik Robert P.¹

Affiliation:

1. Department of Medicinal Chemistry, ‡Microscopy and Analytical Imaging Laboratory, §Mass Spectrometry Laboratory, University of Kansas, Lawrence, Kansas 66045, United States

Funder

University of Kansas

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.chemrestox.6b00270

Reference29 articles.

1. Acetaminophen-induced Liver Injury: from Animal Models to Humans

2. Mechanisms of acetaminophen-induced cell death in primary human hepatocytes

3. Mitochondrial protein adducts formation and mitochondrial dysfunction during N-acetyl-m-aminophenol (AMAP)-induced hepatotoxicity in primary human hepatocytes

4. Paracetamol oxidation: synthesis and reactivity of N-acetyl-p-benzoquinoneimine

5. Synthesis, decomposition kinetics, and preliminary toxicological studies of pure N-acetyl-p-benzoquinone imine, a proposed toxic metabolite of acetaminophen

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