New Approaches to Investigate Drug-Induced Hypersensitivity

Author:

Ogese Monday O.12,Ahmed Shaheda3,Alferivic Ana2,Betts Catherine J.1,Dickinson Anne3,Faulkner Lee2,French Neil2ORCID,Gibson Andrew2,Hirschfield Gideon M.4,Kammüller Michael5,Meng Xiaoli2ORCID,Martin Stefan F.6,Musette Philippe7,Norris Alan2,Pirmohamed Munir28,Park B. Kevin2,Purcell Anthony W.9ORCID,Spraggs Colin F.10,Whritenour Jessica11,Naisbitt Dean J.2

Affiliation:

1. Pathology Sciences, Drug Safety and Metabolism, AstraZeneca R&D, Darwin Building 310, Cambridge Science Park, Milton Road, Cambridge CB4 0WG, U.K.

2. MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Ashton Street, Liverpool L69 3GE, U.K.

3. Alcyomics Ltd c/o Haematological Sciences, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, U.K.

4. Centre for Liver Research, NIHR Birmingham Liver Biomedical Research Unit, Institute of Immunology and Immunotherapy, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.

5. Novartis Institutes for Biomedical Research, Klybeckstrasse 141, CH-4057 Basel, Switzerland

6. Department of Dermatology and Venereology, Allergy Research Group, University of Freiburg, Hauptstraße 7, 79104 Freiburg, Germany

7. Department of Dermatology and INSERM, University of Rouen, 905 Rouen, France

8. The Wolfson Centre for Personalised Medicine, Department of Molecular and Clinical Pharmacology, University of Liverpool, Ashton Street, Liverpool L69 3GE, U.K.

9. Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia

10. Medicines Research Centre, GlaxoSmithKline, Gunnels Wood Road, Stevenage SG1 2NY, U.K.

11. Drug Safety Research and Development, Pfizer, Eastern Point Road, Groton, Connecticut 06340, United States

Funder

AstraZeneca

Medical Research Council

European Research Council

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

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